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1.Y Cheng, et al. Benmelstobart with Anlotinib plus Chemotherapy as First-line Therapy for ES-SCLC: A Randomized, Double-blind, Phase III Trial. 2023 WCLC OA01.03.
2.Nagano T,et al. Cells. 2018 Nov 15;7(11)212.
3.Arulananda S., Do H., Musafer A., Mitchell P., Dobrovic A., John T. J Thorac Oncol. 2017;12:1728–1732.
4.Wang X, Zhou L, Yin JC, et al. J Thorac Oncol. 2019 May;14(5):e85-e88.
5.Marcoux N., Gettinger S.N., O’Kane G. J Clin Oncol. 2019;37:278–285
7.J. Feng, et al. 2021 ELCC 150P.
8.Meiqi Shi,et al. A phase I/II study of TQB2450 (Benmelstobart), a PD-L1 mAb, plus anlotinib in EGFR+ advanced NSCLC patients failed to prior EGFR TKI therapies: Phase II results update. 2023 WCLC
